Phosphorothioate modification

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有關 Phosphorothioate modification?tw 的學術文章scholar.google.com › citationsPhosphorothioate modified oligonucleotide–protein interactions2020年5月1日 · Abstract. Antisense oligonucleotides (ASOs) interact with target RNAs via hybridization to modulate gene expression through different ...Origins of the Increased Affinity of Phosphorothioate-Modified ...2020年3月23日 · The phosphorothioate backbone modification (PS) is one of the most widely used chemical modifications for enhancing the drug-like properties ... tw | twPhosphorothioate Modification of mRNA Accelerates the Rate of ...2020年7月5日 · Abstract Messenger RNAs (mRNAs) with phosphorothioate modification (PS-mRNA) to the phosphate site of A, G, C, and U with all 16 possible ... tw | twAn in vitro DNA phosphorothioate modification reaction - Pu - 20202019年11月21日 · Abstract Phosphorothioation (PT) involves the replacement of a nonbridging phosphate oxygen on the DNA backbone with sulfur. tw | twIn vitro analysis of phosphorothioate modification of DNA reveals ...2015年7月27日 · The purified His-Tag labeled DptC and the captured proteins were applied to Superdex Gel Filtration Column 10/300 GL (GE Healthcare) using ...Phosphorothioate Oligonucleotides - Sigma-AldrichPhosphodiester and phosphorothioate internucleotide linkages. ... As an example, next-generation sequencing adapter oligonucleotides are often modified at ... | Modified internucleoside linkages for nuclease-resistant ...2020年12月8日 · a PS and OMoE refer to the phosphorothioate internucleoside linkage and 2′-O-(2-methoxyethyl) modification of the deoxyribose respectively.Author Summary - PLOSPerformed the experiments: GL TW LL. Analyzed the data: GL XZ ZD XH. ... cleavage of S-modified DNA breaks specifically the phosphorothioate bonds resulting ...Increase oligo stability with phosphorothioate modificationsPhosphorothioate modification. Preventing nuclease degradation. Phosphorothioate bonds substitute a sulfur atom for one of the non-bridging oxygen atoms in the ... twCharacterization of Escherichia coli RNase H Discrimination of DNA ...2021年12月10日 · Phosphorothioate (PS) modification of antisense oligonucleotides (ASOs) is a critical factor enabling their therapeutic use.